No significant effect of rotation was observed in norepinephrine, epinephrine, β-endorphin and arginine-vasopressin levels. Blood adrenocorticotropic hormone and corticosterone significantly increased in 4-month-old males after rotation compared with static controls. Females showed greater responses in defecation and spontaneous locomotor activity during adolescents and/or young-adult period. LiCl-induced conditioned gapings were also decreased with age, but was less pronounced than rotation-induced ones. We found that rotation-induced conditioned gaping, defecation responses and motor disorders were significantly attenuated in middle-aged animals (13- and 14-month-age) compared with adolescents (1- and 2-month-age) and young-adults (4- and/or 5-month-age). Motion sickness was assessed by measurement of autonomic responses (i.e., conditioned gaping and defecation responses), motor impairments (i.e., hypoactivity and balance disturbance) after Ferris wheel-like rotation, and blood hormone levels and central Fos protein expression was also observed. LiCl-induced nausea symptom was evaluated by conditioned gaping. In the present study, we tried to investigate the potential correlates of endocrine and/or neuronal activity with sex and age differences in rats with motion sickness. Many studies have demonstrated sex and age differences in motion sickness, but the underlying physiological basis is still in controversy. Department of Nautical Injury Prevention, Faculty of Navy Medicine, Second Military Medical University, Shanghai, China.Wei Zhou Junqin Wang † Leilei Pan † Ruirui Qi Peng Liu Jiluo Liu Yiling Cai *
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